Welcome to Designs for Health Australia: the trusted practitioner brand for innovative products and education. Learn More

Study Investigates the Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment

vitamin d neurodevelopment

The essential role of Vitamin D in pregnancy

Vitamin D levels are essential during pregnancy, as this plays a role in many physiological processes and infant neurodevelopment. Previous research has shown that approximately 33% of pregnant and lactating women in the U.S. have vitamin D insufficiency. A vitamin D deficiency can be associated with poor health outcomes such as gestational diabetes, asthma, preeclampsia, abnormal skeletal development, low birth weight, and premature birth. 

Nutrient Study explores Vitamin D and infant neurodevelopment.

 According to a study published in Nutrients, researchers investigated the effect of vitamin D status during the first and third trimester of pregnancy on infant neurodevelopment, including language, cognitive function, and motor skills. 

The large, prospective, longitudinal study included 793 women with an average age of 30 years recruited before week 12 of their pregnancy, 422 of which completed postpartum visits assessments.

Vitamin D levels were assessed in both the first and third trimesters of pregnancy. The Bayley Scales of Infant Development-III was conducted 40 days postpartum to the infants.

Vitamin D status in the first and third trimester

In the first trimester, the research team observed that 50.2% of the pregnant women had a vitamin D deficiency, 30.3% had a vitamin D insufficiency, and 19.5% had normal vitamin D levels. 

In the third trimester, 49.7% of the pregnant women had a vitamin D sufficiency, 33.2% had a vitamin D insufficiency, and 17.2% had normal vitamin D levels.

Vitamin D deficiency in the first trimester a predictor of language and cognitive performance

As a result, a vitamin D deficiency in the first trimester of pregnancy predicted worse language and cognitive skills performance. Language performance worsened with lower vitamin D levels equivalent to approximately 10 ng/mL. In the third trimester, this greatly deficient level is associated with lower motor skills.

Vitamin D is essential for optimal infant development 

Women who are pregnant know the importance of adequate folate levels, and vitamin D should be no different. Vitamin D insufficiency is a worldwide primary health concern. Adequate vitamin D levels are essential during pregnancy for optimal infant neurodevelopment.


By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS


Source: Voltas N, Canals J, Hernández-Martinez C, Serrat N, Basora J, Arija V. Effect of vitamin D status during pregnancy on infant neurodevelopment: The ECLIPSES Study. Nutrients 2020;12(10):3196.