GI-Map Tests Multiple Organisms in the Gut – Dr David Brady
Dr David Brady considers how the GI-Map test looks at a whole range of different organisms through genetic or molecular mechanisms. New considerations for the virum, the GI microbiota and autoimmune disease are discussed.
The GI-Map test looks at a whole range of different organisms and through genetic or molecular mechanisms. This includes:
- And so forth
The Virum, the GI Microbiota and Autoimmune Disease
The virum is a very interesting emerging element of the GI microbiota that is important. We look for various pathogenic viruses, like adenovirus and norovirus, which can be the cause of someone’s persistent diarrhea, for instance. But we also look for some other viral organisms that can be conditionally pathogenic or opportunistic, such as cytomegalovirus, Epstein-Barr virus.
These are ubiquitous viruses that many people harbor, that can impart an increased risk for autoimmune disease. Therefore, we do screen for those on the GI-Map test.
Testing for Helicobacter Pylori
00:58 The test does look for the amount of DNA related to helicobacter pylori, the bug associated at times with gastritis, duodenitis, ulceration, and increased risk of stomach cancer.
Up to 50% of people have significant H. Pylori in their upper GI tract, but less than 2% go on to develop serious disease like gastric cancer. So it’s not just the fact that the H. Pylori is there, but it’s more a factor of what is the H. Pylori capable of doing?
Testing what form of H. Pylori is present
Is it a benign form of H. Pylori or is it an aggressive form of H. Pylori? We can determine that with a test as well, because we’re not just looking for the genes to identify H. Pylori, we’re looking for the genetic characteristics of that resident H. Pylori population to produce what are called virulence factors.
We look for a whole list of virulence factors. These various virulence factors that the organism could produce are the elements that create the problems in the tissues that relate to gastritis, ulceration, and gastric cancer.
How does the H. Pylori bug create problems?
02:09 We’re not only looking for the bug, we’re looking for the characteristics and the behaviour that’s capable for the bug to create problems. When we see those things, we need to know what is the best way to treat it.
Use of antibiotics to treat H. Pylori?
If a physician wants to use prescriptive antibiotics to treat the H. Pylori infection, we’re also looking for the genes within the H. Pylori population that would render them resistant to certain antimicrobial agents, so we report that out.
02:40 For instance, in a patient, we may report they have high H. Pylori, they have virulence factors, but if you’re going to treat it, you might not want to use a specific antibiotic – or might want to use a specific antibiotic.
Source: Live interview with Dr David Brady, December 2018, Sydney Australia
Designs for Health Australia proudly presented the
Learn about the clinical applications and the research behind this new DNA/PCR stool test.
Presented by Dr David Brady, Chief Medical Officer for Diagnostic Solutions Laboratories and Dr Oscar Coetzee, Doctor of Clinical Nutrition and Associate Professor.
• This in-depth live seminar was recorded and will be available in early 2019 to DFH Registered Practitioners…