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New Review Demonstrates the Effects of Omega 3 Fatty Acid Supplementation on Vitamin D Levels

omega 3 and vitamin D

Vitamin D and omega-3 fatty acids are essential nutrients involved in numerous metabolic processes that play a significant role in many chronic health conditions. Numerous studies have shown that omega-3 fatty acid supplementation can affect serum vitamin D levels during the past several years, but the results have been inconsistent. These inconsistencies may have been due to the dose, duration, or statistical power of the studies.

Study finds a significant increase in Vitamin D levels after Omega 3 intake 

According to a review published recently in Critical Reviews in Food Science and Nutrition, researchers investigated the effect of omega-3 fatty acid supplementation on vitamin D levels. This meta-analysis consisted of 10 randomised controlled trials with 601 participants who reported circulating vitamin D levels before and after supplementation with omega-3 fatty acids. As a result, there was a significant increase in vitamin D levels after omega-3 fatty acid intake. Vitamin D levels were significantly increased by approximately nine ng/mL when supplementation continued for more than eight weeks and when the baseline vitamin D level was less than 20 ng/mL. In addition, dosing at 1 gram per day resulted in higher vitamin D levels when compared to other dosages, but all doses led to an increase in vitamin D levels.

The interrelationship between nutrients 

The relationship between vitamin D and omega-3 fatty acids is unclear. Deficiencies or insufficiencies of these two nutrients are significant health concerns in clinical practice. This review specifically looked at the effects of omega-3 fatty acids on vitamin D levels; however, it is still optimal to assess both nutrients to address this accordingly. The recent review, as described, demonstrates the significance of the interrelationships between different nutrients and the importance of a comprehensive approach as opposed to monotherapies.

 Previous research has shown the intricate interrelationships among the fat-soluble vitamins, magnesium and vitamin D levels, and omega-3 fatty acid status and B vitamins. A study published in 2018 in the American Journal of Clinical Nutrition demonstrated that magnesium could also increase vitamin D levels similar to omega-3 supplementation. Another study published in the Journal of Alzheimer’s Disease demonstrated that B vitamins had no effect on cognitive decline when omega-3 levels were low. Still, when omega-3 levels were in a normal upper range, B vitamins slowed cognitive decline and brain atrophy.

By Michael Jurgelewicz, DC, DACBN, DCBCN