Welcome to Designs for Health Australia: the trusted practitioner brand for innovative products and education. Learn More

Review demonstrates the benefits of collagen peptides on osteoarthritis

collagen for osteoarthritis

Collagen, Osteoarthritis and the relief of symptoms

Osteoarthritis (OA) is a major cause of musculoskeletal morbidity and functional loss, and the most prevalent of the musculoskeletal conditions. At this time, there is no medical treatment effective for slowing down OA progression long term or for promoting disease reversal or prevention. The standard of care for OA management focuses primarily on partially and temporarily alleviating symptoms. A review considers if collagen can provide relief.

Collagen efficacy for relief of osteoarthritis symptoms

According to a review published recently in International Orthopaedics, researchers demonstrated the efficacy of collagen supplementation for improving osteoarthritis symptoms.

The review consisted of 5 randomized controlled trials (RCTs) published between 2009 and 2016, encompassing 519 patients. The duration of treatment ranged from 10 to 48 weeks. Treatment with collagen supplementation demonstrated a significant reduction of the total WOMAC index, and a significant reduction in stiffness and VAS score.

Beneficial effects of collagen for treatment of OA?

The possible beneficial effects of collagen for the treatment of OA have been controversial. It is essential to use collagen peptides that have a low molecular weight, and which have demonstrated efficacy for specific applications, including osteoarthritis and osteoporosis.

Hydrolysed collagen peptides

Hydrolysed collagen peptides, which are rich in proline and hydroxyproline, promote the synthesis of hyaluronic acid from synovial cells. Upon digestion, collagen is mainly broken down into single amino acids and dipeptides. These enter the bloodstream and accumulate in joint cartilage. They stimulate the biosynthesis of cartilage extracellular matrix by increasing type II collagen and proteoglycan production.

Meta-analysis demonstrates benefits of collagen

The decrease of both total WOMAC index and VAS score shown in this meta-analysis demonstrates that collagen is effective for improving OA symptoms. Other benefits of collagen supplementation include improving skin elasticity, sarcopenia, osteoporosis, blood pressure, and insulin resistance.

Research and References

By Designs for Health USA researcher and writer, Michael Jurgelewicz, DC, DACBN, DCBCN, CNS

Source: Garcia-Coronado JM, Martinez-Olivera L, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2018 Oct 27. doi: 10.1007/s00264-018-4211-5.