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Bone-Muscle Crosstalk: Insights for Addressing Sarco-osteoporosis

Bone Muscle Crosstalk

Sarco-osteoporosis and How Our Muscles & Bones Interact

The muscles and bones in our body are a team. Efforts to preserve the health of one may also help protect the other. It is important to understand how muscles and bones interact to support musculoskeletal health as we age.

During the aging process, sarcopenia (low muscle mass) and osteoporosis (low bone mass) often develop side by side. When both diseases (sarcopenia and osteoporosis) are present, this is referred to as sarco-osteoporosis.

Biochemical Bone-Muscle Communication

Until recently, it was believed that the only interaction between muscle and bone was mechanical interaction. New evidence indicates that muscles and bones are also linked by biochemical communication as “crosstalk” through the molecules they secrete.


Muscle cells synthesize and release small messenger proteins called myokines, particularly when muscles contract during physical activity. Myokines can communicate with bone, muscle, and other tissues and organs. Some myokines support the formation and maintenance of the musculoskeletal system.

One osteogenic myokine is irisin, which promotes an increase in the mass and strength of cortical bone, making up 80% of the body’s skeleton. Insulin-like growth factor 1 (IGF-1) is also a myokine, which stimulates bone anabolism and promotes muscle growth.

Another myokine, β-aminoisobutyric acid (BAIBA), may help prevent bone loss during immobilization. BAIBA helps maintain the bone cells’ mitochondria and helps protect osteocytes from apoptosis induced by reactive oxygen species. However, osteocyte receptors for BAIBA are significantly downregulated as we age.


Bone cells also secrete biochemical messenger compounds, which are referred to as osteokines. One osteokine is prostaglandin E2 (PGE2). Preliminary in vitro research suggests PGE2 and other osteokines may induce the formation of muscle tissue.

Scientists speculate that administering PGE2, irisin, and other molecules that participate in bone-muscle crosstalk may have clinically relevant benefits for sarco-osteoporosis. More research is needed in this area.

Protein Support for Bones and Muscles to Prevent Sarco-Osteoporosis

Fortunately, many nutritional factors support musculoskeletal health, in addition to resistance exercise and other physical activity.

Protein intake supports both muscle and bone health. A high protein intake was once thought to harm bone health. However, current scientific consensus indicates that higher protein intake does not appear to adversely affect bones in generally healthy people, especially if calcium intake is adequate. Moreover, protein intake may support intestinal calcium absorption.

Protein may also support IGF-1 production. Animal research has shown increased IGF-1 levels after supplementation with essential amino acids.  Branched-chain amino acids, which include leucine, isoleucine, and valine, may be beneficial, especially for supporting muscle protein synthesis.

To support bone and muscle health, a daily protein intake of 1.0 g to 1.2 g per kg of body weight is recommended for healthy, older adults.  Individuals who are malnourished or at risk of malnutrition due to acute or chronic illness may need additional protein.

Some evidence suggests that at least 20 g to 25 g of high-quality protein per meal is required for appropriate stimulation of postprandial muscle protein synthesis over a 24-hour period. However, protein intake tends to be relatively low at breakfast, which may limit potential support for muscle health.

Vitamin and Mineral Support for Muscles and Bones and Prevent Sarco-Osteoporosis

A healthy diet helps supply the vitamins and minerals needed to support muscle and bone health. These nutrients include vitamins D and K, calcium, magnesium, and zinc. In addition, vitamin D synthesis can be triggered endogenously through sunlight exposure, and vitamin K can be produced by gastrointestinal bacteria.

Many factors, such as poor dietary choices, limited sun exposure, and impaired intestinal health, lead to insufficient nutrients that support the musculoskeletal system. Optimizing the intake of certain vitamins and minerals may support musculoskeletal health and bone-muscle crosstalk in the following ways:

By Marsha McCulloch, MS, RDN, LN