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[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Effects of Delta-tocotrienol Supplementation on Glycaemic Control in Individuals with Prediabetes [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Prediabetes is an increasingly common condition. More than 1 in 3 American adults (approximately 96 million) have prediabetes, and of those, more than 80% are unaware of their prediabetic status according to the CDC. Oxidative stress and chronic inflammation are contributing factors to the development of insulin resistance, prediabetes, and type 2 diabetes mellitus (T2DM). Delta-tocotrienol has been shown in research to support the body’s response to oxidative stress and inflammation. Researchers investigated the potential impact...

08 November, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Emulsification by TPGS or Quillaja Extract Increased Absorption and Affected Metabolism of Berberine in Humans [/vc_column_text][vc_empty_space height="20px"][/vc_column][/vc_row][vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_column_text css=""]Formulas/Compounds:Berb-Evail Background Although a potent botanical with anti-hyperglycemic and antimicrobial properties, berberine has notoriously poor bioavailability, with an absorption rate of less than 1% in humans. To determine the potential for enhancing the uptake of berberine, researchers investigated emulsification applications with berberine in human subjects. Objectives The objectives of this study were to determine whether emulsification by tocophersolan (TPGS) or quillaja extract affects the absorption and metabolism of orally ingested berberine in human...

06 November, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] The Effects of Oral Supplementation with Geranylgeraniol (GG) Sourced from Annatto on Sexual Health in Males and Females [/vc_column_text][vc_empty_space][vc_column_text css=""]Formula/Nutrient: Trans-Geranylgeraniol (as GG-Gold™) Background Population-based studies show that testosterone levels in men decrease with age,¹ and this decline has been linked with chronic diseases and shortened life expectancy, lacking an ability to thrive.²⁻⁷ Testosterone in men is produced by the Leydig cells in testicles, sharing the common origin of cholesterol through the mevalonate pathway.⁸ As a central part of the mevalonate pathway, GG is crucial in regulating testosterone production. In testis-derived cells, GG was shown to...

14 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Effect of Annatto-Derived Geranylgeraniol (GG) on Statin-Associated Myopathy [/vc_column_text][vc_empty_space][vc_column_text css=""]Formula/Nutrient: Trans-Geranylgeraniol (as GG-Gold™) Background The mevalonate pathway, known to be responsible for the body’s synthesis of cholesterol, is also one of the main targets in the fight against cardiovascular disease. High cholesterol has been indisputably linked to an increased risk of heart disease, the leading cause of death in the United States. As of 2017, 95 million US adults have elevated cholesterol (> 200mg/dL)¹, and nearly 29 million Americans have very high cholesterol levels (>240mg/dL). It has been suggested that more than half of US adults would...

14 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Assessment of Diabetes Control, Cost of Care, and Quality of Life Utilizing a Functional Medicine Approach in Addition to Usual Care vs. Usual Care Alone [/vc_column_text][vc_empty_space][vc_column_text css=""]Formulas/Compounds: GI Revive®, Immunitone Plus™, Oil of Oregano.   Background Type 2 Diabetes mellitus (T2DM) is a chronic, complex disease process, characterized by persistent hyperglycemia, systemic cellular insulin resistance, impaired pancreatic islet function, and various comorbidities if managed poorly. A functional medicine (FM) approach that addresses aspects of immune balance, gastrointestinal function, glucose metabolism, satiety, and bioenergetics holds promise as an effective care model. Objectives This is a prospective, randomized, controlled, open-label...

14 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Functional Medicine in Asthma (FAst) Study [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: Immunitone Plus™, Inflammatone™, Oil of Oregano, Q-Evail® 200 Background This is a pilot, proof of concept, early-stage study. The study goal is to determine whether the Functional Medicine approach to the treatment of moderate to severe persistent asthma enhances standard guideline-based care with respect to asthma outcomes. Functional Medicine is a holistic approach to treating chronic conditions by attempting to address the underlying causes of chronic disease states. The purpose is to address the whole person, not just a set of symptoms. The patient...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: CraveArrest™, EndoTrim™, GI Revive®, Immunitone Plus™, Inflammatone™, Neurolink™, Oil of Oregano, Organic PurePea™, Q-Evail® 200 Background Type 2 Diabetes mellitus (T2DM) is a chronic, complex disease process, characterized by persistent hyperglycemia, systemic cellular insulin resistance, impaired pancreatic islet function, and various comorbidities if managed poorly. A functional medicine (FM) approach that addresses aspects of immune balance, gastrointestinal function, glucose metabolism, satiety, and bioenergetics holds promise as an effective care model. Objectives This is a prospective, randomized, controlled, open-label clinical trial with a 1:1 randomization of patients with diabetes who have been...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formula/Nutrient: Trans-Geranylgeraniol (as GG-Gold™) Background The mevalonate pathway, known to be responsible for the body’s synthesis of cholesterol, is also one of the main targets in the fight against cardiovascular disease. High cholesterol has been indisputably linked to an increased risk of heart disease, the leading cause of death in the United States. As of 2017, 95 million US adults have elevated cholesterol (> 200mg/dL)¹, and nearly 29 million Americans have very high cholesterol levels (>240mg/dL). It has been suggested that more than half of US adults would benefit from taking statin...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formula/Nutrient: Trans-Geranylgeraniol (as GG-Gold™) Background Population-based studies show that testosterone levels in men decrease with age,¹ and this decline has been linked with chronic diseases and shortened life expectancy, lacking an ability to thrive.²⁻⁷ Testosterone in men is produced by the Leydig cells in testicles, sharing the common origin of cholesterol through the mevalonate pathway.⁸ As a central part of the mevalonate pathway, GG is crucial in regulating testosterone production. In testis-derived cells, GG was shown to regulate the steroidogenesis pathway, enhancing not only testosterone synthesis, but also synthesis of its precursor,...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Tocotrienol Supplementation Led to Higher Serum Levels of Lysophospholipids but Lower Acylcarnitines in Postmenopausal Women [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Bone loss is a common occurrence in postmenopausal women. Some changes in bone metabolism related to estrogen deficiency have been associated with oxidative stress, while inflammation exerts a significant influence on bone turnover. Tocotrienols (TT) may support mitochondrial health and the body’s response to oxidative stress and inflammation. TTs have been shown in clinical studies to improve the bone turnover rate in postmenopausal women. Objectives The objectives of this double-blind placebo-controlled metabolomic study...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Effects of Delta-tocotrienol Supplementation on Liver Enzymes, Inflammation, Oxidative stress and Hepatic Steatosis in Patients with Nonalcoholic Fatty Liver Disease [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Nonalcoholic fatty liver disease (NAFLD) is one of the primary causes of liver-associated morbidity and mortality. The pathogenesis of nonalcoholic fatty liver disease may be associated with oxidative stress and inflammation. Delta-tocotrienol, a form of vitamin E that has been shown in studies to have higher bioavailability and potency than many other forms of vitamin E, may support a healthy response to inflammation and oxidative stress. Objectives This double-blind...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Tocotrienol Supplementation Suppressed Bone Resorption and Oxidative Stress in Postmenopausal Osteopenic Women [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Bone loss is a common occurrence in postmenopausal women. Some changes in bone metabolism related to osteopenia have been associated with oxidative stress. Tocotrienols (TT) may support healthy bone metabolism through their ability to protect osteoblasts, suppress the differentiation of osteoclasts, and support the body’s response to oxidative stress and inflammation. Objectives The objectives of this novel study are to assess the efficacy of supplementation with DeltaGold® delta-tocotrienol in postmenopausal women presenting with low bone mass. Methods This placebo-controlled...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Delta-tocotrienol Supplementation Improves Biochemical Markers of Hepatocellular Injury and Steatosis in Patients with Nonalcoholic Fatty Liver Disease [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Nonalcoholic fatty liver disease (NAFLD) is one of the primary causes of liver-associated morbidity and mortality. The pathogenesis of nonalcoholic fatty liver disease may be associated with oxidative stress and inflammation. Delta-tocotrienol, a form of vitamin E that has been shown in studies to have higher bioavailability and potency than many other forms of vitamin E, may support a healthy response to inflammation and oxidative stress. Objectives This double-blind randomized placebo-controlled study...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] A Novel Mixture of δ-Tocotrienol, Vitamin D3, Resveratrol Significantly Decreases Diabetes Biomarkers [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Oxidative stress and chronic inflammation are contributing factors to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Delta-tocotrienol, vitamin D3, and resveratrol have been shown in research to support the body’s response to oxidative stress and inflammation. Researchers investigated the potential impact of the combination of these nutrients on individuals with T2DM. Objectives The objectives of this placebo-controlled study were to determine whether the combination of delta-tocotrienol, vitamin D3, and resveratrol is more efficacious...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Delta-tocotrienol in Recurrent Ovarian Cancer: A Phase II Trial [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Ovarian cancer recurs in most cases and is associated with a high rate of mortality. It is common in this population to develop a resistance to chemotherapy. Bevacizumab is a common treatment for ovarian cancer that targets the vascular endothelial growth factor (VEGF). Delta-tocotrienol is a form of vitamin E thought to modulate angiogenic activity through the suppression of VEGF. Objectives This phase II trial assessed the effect of a combination of bevacizumab and a tocotrienol supplement containing 90% delta-tocotrienol...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Dose-dependent Modulation of Lipid Parameters, Cytokines and RNA by δ-tocotrienol in Hypercholesterolemic Subjects [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Hypercholesterolemia has been associated with oxidative stress and an inflammatory response. Delta-tocotrienol, a highly bioavailable form of vitamin E, has been shown to influence lipid levels and biomarkers related to inflammation and oxidative stress. Objectives This study evaluated the impact of different dosages of delta-tocotrienol on lipid biomarkers, certain cytokines, and the gene expression of select circulating microRNAs (miRNAs) in individuals with hypercholesterolemia. Methods Thirty-one individuals over the age of fifty with hypercholesterolemia participated in this 30-week-long study....

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Effects of Delta-tocotrienol Supplementation on Glycemic Control, Oxidative Stress, Inflammatory Biomarkers, and miRNA Expression in Type 2 Diabetes Mellitus [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Oxidative stress and chronic inflammation are contributing factors to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Delta-tocotrienol has been shown to support the body’s response to inflammation and oxidative stress. Researchers investigated the impact of supplementation with delta-tocotrienol on biomarkers related to T2DM. Objectives The objectives of this randomized placebo-controlled study were to investigate the potential supportive role of delta-tocotrienol in relation to T2DM and its...

11 October, 2024

[vc_row css_animation="" row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern"][vc_column][vc_empty_space][vc_column_text css=""] Impact of δ-Tocotrienol on Inflammatory Biomarkers and Oxidative Stress in Hypercholesterolemic Subjects [/vc_column_text][vc_empty_space][vc_row_inner row_type="row" type="full_width" text_align="left" css_animation=""][vc_column_inner][vc_column_text css=""] Formulas/Compounds: DeltaGold® tocotrienols Background Hypercholesterolemia has been associated with oxidative stress and an inflammatory response. Delta-tocotrienol, a highly bioavailable form of vitamin E, has been shown to influence lipid levels and biomarkers related to inflammation and oxidative stress. Objectives This study evaluated the impact of varied delta-tocotrienol dosages on numerous inflammatory and oxidative biomarkers in individuals with hypercholesterolemia. Methods Thirty-one individuals over the age of fifty with hypercholesterolemia participated in this 30-week-long study. Dietary intervention with the American Heart Association Step 1 diet...

11 October, 2024
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